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KMID : 0391520160240030102
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Journal of the Korean Child Neurology Society
2016 Volume.24 No. 3 p.102 ~ p.108
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The Risk Factors for Relapse of Unprovoked Seizures after Drug Withdrawal in Epileptic Children
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Kim So-Ri-Na
Lee Ju-Yeon
Oh Min-Su
Kim Yoon-Joo
Choi Jae-Hong
Kang Hyun-Sik
Han Kyoung-Hee
Kim Young-Don
Kang Ki-Soo
Kim Seung-Hyo
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Abstract
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Purpose: We evaluated the risk factors for relapse of unprovoked seizures after drug withdrawal in epileptic children in Jeju Island, South Korea.
Methods: A population-based retrospective study was performed in 632 children whose first unprovoked seizure occurred between March 2001 and May 2013. The study included children experiencing a seizure free-state during a minimum of 2- year treatment period with anti-epileptic drugs (AEDs) with at least 1-year follow-up after AED withdrawal at the Pediatric Department at the Jeju National University Hospital.
Results: Sixty-eight children including 36 boys and 32 girls, met the above-mentioned inclusion criteria, and subsequent seizure relapse occurred in 23 patients (33.8%). The mean age at the first unprovoked seizure was 79.1±45.9 months and the mean number of unprovoked seizures was 7.1±4.9. Partial and generalized seizures were observed in 19 and 49 patients, respectively. Several variables such as the age at onset of the first seizure, late remission, duration of AED treatment longer than 2 years, and complex febrile seizures before the first unprovoked seizure affected the risk for relapse. Multivariate analysis identified complex febrile seizure, age at the first seizure onset being more than 10 years, and late remission as significant predictors of relapse.
Conclusion: We identified three independent risk factors for relapse following an unprovoked seizure in epileptic children after AED withdrawal : complex febrile seizure, age at the first seizure onset being more than 10 years, and late remission.
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KEYWORD
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Relapse, Epilepsy, Complex febrile seizure
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